2-BROMO-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-ONE

2-BROMO-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-ONE - Names and Identifiers

Name	4-(trifluoromethyl)phenacyl bromide
Synonyms	ethyl chloro(difluoro)acetate 4-TRIFLUOROMETHYLPHENACYL BROMIDE 4-(trifluoromethyl)phenacyl bromide 4'-(TRIFLUOROMETHYL)PHENACYL BROMIDE 2-BROMO-4'-(TRIFLUOROMETHYL)ACETOPHENONE 2-broMo-1-(4-(trifluoroMethyl)phenyl)ethanone 2-Bromo-1-[4-(trifluoromethyl)phenyl]ethan-1-one 2-BROMO-1-[4-(TRIFLUOROMETHYL)PHENYL]-1-ETHANONE 2-BROMO-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-ONE 2-Bromo-4'-(trifluoromethyl)acetophenone, 2-Bromo-1-[4-(trifluoromethyl)phenyl]ethan-1-one
CAS	383-53-9
EINECS	609-544-9
InChI	InChI=1/C4H5ClF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3

2-BROMO-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-ONE - Physico-chemical Properties

Molecular Formula	C9H6BrF3O
Molar Mass	267.04
Density	1.592±0.06 g/cm3(Predicted)
Melting Point	45 °C
Boling Point	264.2±40.0 °C(Predicted)
Flash Point	28.9°C
Solubility	soluble in Methanol
Vapor Presure	48.8mmHg at 25°C
Appearance	powder to crystal
Color	White to Yellow to Orange
Storage Condition	2-8°C
Refractive Index	1.374

2-BROMO-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-ONE - Risk and Safety

Risk Codes	R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing.
UN IDs	1759
WGK Germany	3
HS Code	29147000
Hazard Class	CORROSIVE
Packing Group	III

2-BROMO-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-ONE - Introduction

4-(trifluoromethyl)phenacyl bromide, chemical formula C9H6BrF3O, molecular weight of 257.04g/mol. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Colorless crystalline solid
-Melting Point: 79-81 degrees Celsius
-Boiling point: 205-207 degrees Celsius
-Solubility: Soluble in organic solvents such as ether and dichloromethane

Use:
- 4-(trifluoromethyl)phenacyl bromide can be used as an important intermediate in organic synthesis. It has active fluorinated reagent activity, can be used for the synthesis of aromatic compounds, ketones and esters.
-It can also be used as a key intermediate in drug synthesis, such as the synthesis of anti-cancer drugs.

Preparation Method:
- 4-(trifluoromethyl)phenacyl bromide is usually prepared by the following reaction: First, the α-hydrogen atom in acetophenone is brominated with methyl bromide to obtain α-bromoacetophenone. Then, α-bromoacetophenone was subjected to trifluoromethylation reaction using trifluoromethyl mercaptan (TFMS) to obtain the final product 4-(trifluoromethyl)phenacyl bromide.

Safety Information:
- 4-(trifluoromethyl)phenacyl bromide is irritating and should avoid contact with skin and eyes. Use appropriate protective gloves, safety glasses and personal protective equipment such as laboratory coats.
-The compound is an organic halogenated compound, which may have certain toxicity to the environment and biological systems, and should be used and disposed of under suitable facilities and conditions.
-When using or disposing, please follow the relevant safety operation procedures and comply with the requirements of laws and regulations.

Last Update：2024-04-09 21:01:54